Research Services on the Gut Microbiota of Organoids

I. Examples of fecal water co-culture services

Figure 1: Effect of Yaq-001 on the permeability of small intestinal-like organs.

A. Small intestinal organoids from C57BL/6 mice were cultured and polarity flipped (apical-out); F-actin labeled intestinal epithelial cell microvilli.

B. Polarity-turned organoids were differentiated and matured under suspension culture conditions and expressed cup cell marker (MUC2);

C. Fecal water sourced from different treatment groups of liver injury was co-cultured with organoids, and Yaq-001 reduced the barrier permeability of intestinal organoids

(Liu J, et al. Gut 2024;0:1-15. doi:10.1136/gutjnl-2023-330699).

II. Probiotic co-culture service cases

                Mucus layer: WGA                                    Mucus layer: Villin

Organochip simulates the microenvironment of intestinal flora

Intestinal organ chips, which can simulate the intestinal absorption of food and drugs, protective effects of probiotics and other applied research.

                   Microchip